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0|0|MIDODRINE CHLORHYDRATE|Irleana||20:01:51|10/16/2004|[font size="1" color="#5B64B0"]Modifié le 16-10-04 à 20:05  (GMT)[/font][p]%0D%0ABonsoir%2C%0D%0A%0D%0AIl est possible que ce post reste longtemps sans r%E9ponse.%0D%0AIl est possible que quelqu%27un ait tout simplement entendu parler de cette mol%E9cule%2C ou qu%27une autre personne se sente elle-aussi concern%E9e.%0D%0AIl est possible que cela permette tout simplement de toucher et d%27atteindre des patients sous le m%EAme traitement.%0D%0A%0D%0AIl s%27agit d%27un stimulant cardiaque %28ADRENERGIQUE ET DOPAMINERGIQUE%29%0D%0AUn traitement au c%F4ut %E9l%E9v%E9 de 213%2C6 euros%2C soumis %E0 une r%E9serve hospitali%E8re...Des tests sont encore r%E9alis%E9s par de nombreux ing%E9nieurs en biologie%2C par des services de toxicologie..Car le Gutron serait %E0 90%25 apparent%E9 %E0 un amph%E9tamine. Apr%E8s de multiples errements th%E9rapeutiques%2C il m%27a %E9t%E9 prescrit  en bou%E9e de secours qui s%27%E9ternise.Puisqu%27il n%27existe aucune mol%E9cule similaire %E0 l%27efficacit%E9 prouv%E9e.%0D%0A%28Effet placebo oblige%29.%0D%0AMon cardiologue%2Cne m%27avait jamais rien dit..et un jour de novembre 2003 aux urgences neurologiques%2C j%27ai appris beaucoup de choses..%0D%0AUn m%E9dicament toujours en phase de test et qui n%27attendrait jamais les officines de villes..avant que ce soit lui qui peut-%EAtre ne m%27atteigne ..%0D%0AEnfin%2C il est vrai que j%27ai tout de m%EAme entendu ici et l%E0 beaucoup de choses%2C et qu%27il reste indispensable de faire la part des choses.%0D%0A%0D%0APersonnellement depuis le mois de f%E9vrier 2002%2C je suis %E0 20 mg par jou%28soit huit comprim%E9s en trois prises%29%0D%0A%3EEn traitement prolong%E9%2C cette dose peut %EAtre r%E9duite selon la r%E9ponse clinique %E0%3A %BD comprim%E9 %E0 2%2C5 mg de midodrine HCl 2%D7%2Fjour ou 3 gouttes de solution %E0 1%25 2%D7%2Fjour.Si n%E9cessaire%2C la dose peut %EAtre augment%E9e jusqu%27%E0 concurrence de 2 comprim%E9s %E0 2%2C5 mg de midodrine HCl 2%D7%2Fjour ou 15 gouttes de solution %E0 1%25 2%D7%2Fjour.%3C%0D%0APour les cas plus atypiques%2C et les plus s%E9v%E8res%0D%0A%3CLa dose doit %EAtre adapt%E9e selon les cas.Dans certains cas%2C il peut %EAtre indiqu%E9 d%27augmenter la dose jusqu%27%E0 15 mg%2Fjour.%3C%0D%0A%0D%0A%0D%0A%0D%0AEntre quelques pr%E9cautions de premiers plan j%27ai appris que%3A%0D%0A%3ELes patients trait%E9s par Gutron doivent %E9viter de prendre simultan%E9ment d%27autres substances alpha-sympathomim%E9tiques%2C y compris les m%E9dicaments en vente libre tels des anti-grippaux%2C gouttes pour le nez et autres %28voir %E9galement sous %ABInteractions%BB%29.%3C%0D%0A%0D%0APuis %5Bb%5Dla liste d%27effets seconds%5B%2Fb%5D s%27est d%E9li%E9e et peu %E0 peu v%E9rifi%E9e..%0D%0APARESTHESIE %28CERTAIN RARE%29 %5Bb%5Dfourmillements etc..%5B%2Fb%5D%0D%0AHYPERTENSION ARTERIELLE %28CERTAIN RARE%29%0D%0ACondition%28s%29 Favorisante%28s%29 %3A %0D%0AFORTE DOSE%0D%0ASurtout en position couch%E9e. %5Bb%5Dsurtout les premiers mois %5B%2Fb%5D%0D%0ARASH %28CERTAIN FREQUENT%29 %5Bb%5Dsemblants de plaques rouges de boutons%5B%2Fb%5D%0D%0ANAUSEE %28CERTAIN RARE%29 %0D%0ADOULEUR EPIGASTRIQUE %28CERTAIN RARE%29 %0D%0ATACHYCARDIE %28CERTAIN RARE%29 %0D%0APALPITATION %28CERTAIN RARE%29 %0D%0ACEPHALEE %28CERTAIN RARE%29 %0D%0AVERTIGE %28CERTAIN RARE%29 %0D%0AHORRIPILATION %28CERTAIN %29 %5Bb%5Deffet chair de poule %5B%2Fb%5D%0D%0ARETENTION D%27URINE %28CERTAIN %29%0D%0A- JAMA 1997%3B277%3A1046-1051. %0D%0AAPLASIE MEDULLAIRE %28A CONFIRMER %29%0D%0AQuelques cas r%E9pertori%E9s.%0D%0A%0D%0A%5Bb%5DEffets sur la descendance%5B%2Fb%5D%0D%0ANON TERATOGENE CHEZ L%27ANIMAL %0D%0AINFORMATION MANQUANTE DANS L%27ESPECE HUMAINE %0D%0A%0D%0ACertains parlent d%27effets seconds accr%FBs par un r%E9gime trop riche en sel.. Il est pr%E9f%E9rable et conseill%E9e d%27%E9viter toute prise d%27alcool.%0D%0ACertaines personnes dialys%E9s ont recours %E0 ce traitement avant la dialyse%2C par une prise hebdomadaire.%0D%0A%0D%0A%5Bb%5DEt vous%2Cpersonnellement%5B%2Fb%5D%0D%0AComment avez-vous connu la midodrine%3F%0D%0AFa%EEtes-vous l%27objet de recherches%3F Dans un CHU%3F%0D%0AVous %EAtes-vous senti en confiance avec le prescripteur%3F%0D%0AQue vous-a-t-on propos%E9 %E0 la suite du sevrage de la midodrine%3F%0D%0APuisqu%27il ne semble exister aucune mol%E9cule de substitut efficace...%0D%0AFa%EEtes vous l%27objet de surveillance h%E9pathique et r%E9nale%3F%0D%0AComment vivez-vous au jour le jour%3F%0D%0AAvez-vous eu une scolarit%E9 perturb%E9e%3F De mon c%F4t%E9%2C oui tout en ayant eu %22la chance%22 de ne jamais avoir eu %E0 redoubler..%0D%0AAvez-vous atteint le seuil z%E9ro de malaises%3F %0D%0AParvenez-vous %E0 g%E9rer les effets seconds%3F%0D%0AEtes vous satisfaite des effets b%E9n%E9fiques et positifs%2C de la qualit%E9 de vie qu%27a apport%E9e le Gutron%3F%0D%0A%0D%0AJ%27aurais encore beaucoup de choses %E0 t%E9moigner.%0D%0AMais c%27est d%E9j%E0 beaucoup ainsi. Je pr%E9f%E8re nettement en rester l%E0.%3B-%29%0D%0A%0D%0AMerci d%27avance d%27avoir pr%EAter attention %E0 ce post.%0D%0AA bient%F4t je l%27esp%E8re.%0D%0ABonne continuation.%0D%0ACordialement.%0D%0Aet %5Bb%5DMerci pour tout.%5B%2Fb%5D%0D%0A
1|1|RE%3A MIDODRINE CHLORHYDRATE|Irleana||22:26:49|11/07/2004|Bonsoir%2C%0D%0A%0D%0AVoici%2C voil%E0 un post qui n%27aura pas trop %E9t%E9 perturb%E9 des pannes d%27ordi %3B-%29%0D%0AQuasi r%E9par%E9 ce soir vers 21 heures 10.. %3AD%0D%0AM%27enfin %3Ao%2C tout r%E9install%E9%2C chang%E9 de bo%EEte livebox et %3AD%0D%0ATout va tr%E8s bien sauf la bo%EEte d%27envoi..Plus aucun message ne peut partir..Ils arrivent%2C c%27est d%E9j%E0 %E7a..M%27enfin..%0D%0A%0D%0ADonc revenons %E0 nos moutons%2C %E7a ne m%27%E9tonne pas qu%27il n%27y ait pas eu de nouveau ici.%0D%0AJ%27en ai eu un petit peu%2C pas des masses mais un petit pas grand chose..%0D%0APour les anglicistes%2C le gutron %28midodrine%29 c%27est%3A%0D%0A%5Bb%5DAmatine%2C ProAmatine%5B%2Fb%5D %0D%0A%0D%0AMidodrine Hydrochloride%0D%0A %0D%0A  %0D%0ABrand Name%28s%29%3A%0D%0AAmatine%2C ProAmatine %0D%0A%0D%0ADrug Class%3A%0D%0AAlpha-adrenergic agonist%0D%0A%0D%0AAvailable OTC%3F%3A No%0D%0AAvailable Generic%3F%3A No%0D%0A %0D%0AAvailable In %0D%0AWhy Prescribed %0D%0AHow It Works %0D%0ARange and Frequency %0D%0AOnset of Effect %0D%0ADuration of Action %0D%0ADietary Advice %0D%0AStorage %0D%0AMissed Dose %0D%0AStopping the Drug %0D%0AProlonged Use %0D%0AOver 60 %0D%0ADriving and Hazardous Work %0D%0AAlcohol %0D%0APregnancy %0D%0ABreast Feeding %0D%0AInfants and Children %0D%0ASpecial Concerns %0D%0AOverdose Symptoms %0D%0AWhat to Do %0D%0ADrug Interactions %0D%0AFood Interactions %0D%0ADisease Interactions %0D%0A  %0D%0A%0D%0AAvailable In%0D%0ATablets %0D%0A%0D%0AWhy Prescribed%0D%0ATo treat severe cases of orthostatic hypotension %28extremely low blood pressure%2C causing symptoms of dizziness and faintness%2C especially when rising from a seated or lying position%29. Used when standard care%2C such as support stockings%2C fluid expansion%2C and lifestyle changes%2C is ineffective. %0D%0A%0D%0AHow It Works%0D%0AMidodrine causes constriction of the smooth muscles surrounding the blood vessels. This effect narrows the width of the blood vessels%2C causing blood pressure to rise%2C thus helping to correct low blood pressure on standing. %0D%0A%0D%0ARange and Frequency%0D%0ATo start%2C 10 mg%2C 3 times a day during waking hours%2C at intervals of 4 hours. Suggested dosage schedule is to take the medication shortly after rising%2C then at midday%2C and then late afternoon %28before 6 pm%29. Blood pressure should be monitored while sitting and lying down at the outset of treatment for possible adjustment of doses. %0D%0A%0D%0AOnset of Effect%0D%0AWithin 1 hour. %0D%0A%0D%0ADuration of Action%0D%0AFrom 2 to 3 hours. %0D%0A%0D%0ADietary Advice%0D%0ANo special restrictions.  %5Bb%5Det le sel%3F%5B%2Fb%5D%0D%0A%0D%0AStorage%0D%0AStore in a tightly sealed container away from heat%2C moisture%2C and direct light. %0D%0A%0D%0AMissed Dose%0D%0ATake it as soon as you remember. If it is near the time for the next dose%2C skip the missed dose and resume your regular dosage schedule. Do not double the next dose. %0D%0A%0D%0AStopping the Drug%0D%0AThe decision to stop taking the drug should be made in consultation with your physician. %0D%0A%0D%0AProlonged Use%0D%0ASee your doctor regularly for measurements of blood pressure while sitting and lying down if you must take this drug for a prolonged period. Periodic tests for liver and kidney function will be done. %0D%0A%0D%0AOver 60%0D%0ANo special problems are expected. %0D%0A%0D%0ADriving and Hazardous Work%0D%0ADo not drive or engage in hazardous work until you determine how the medicine affects you. %0D%0A%0D%0AAlcohol%0D%0AAvoid alcohol when using this medication%3B it may interfere with proper control of blood pressure. %5Bb%5Doui %E7a augmente l%27effet%2C donc ici en France%2C c%27est beaucoup plus explicite %5B%2Fb%5D%0D%0A%0D%0APregnancy%0D%0AAdequate studies have not been done. Before taking midodrine%2C tell your doctor if you are pregnant or plan to become pregnant. Discuss with your doctor the relative benefits and possible risks to the unborn child when using this drug during pregnancy. %0D%0A%0D%0ABreast Feeding%0D%0AMidodrine may pass into breast milk%3B caution is advised. Consult your doctor for specific advice. %0D%0A%0D%0AInfants and Children%0D%0AThe safety and effectiveness of midodrine in children and infants have not been established. %0D%0A%0D%0ASpecial Concerns%0D%0AThe last dose of midodrine should be taken at least 3 hours before bedtime. Use of this drug is not recommended for patients who have persistent and excessively high systolic blood pressure. %0D%0A%0D%0AOverdose Symptoms%0D%0AGoose bumps%2C sensation of coldness%2C decreased urine output%2C rapid heartbeat%2C ringing in the ears. %0D%0A%0D%0AWhat to Do%0D%0AIt is not known whether an overdose of midodrine is life-threatening. However%2C if someone takes a much larger dose than prescribed%2C call your doctor%2C emergency medical services %28EMS%29%2C or the nearest poison control center immediately. %0D%0A%0D%0ADrug Interactions%0D%0AConsult your doctor for specific advice if you are taking cardiac glycosides%2C phenylephrine%2C pseudoephedrine%2C beta-blockers%2C phenylpropanolamine%2C dihydroergotamine%2C fludrocortisone acetate%2C prazosin%2C terazosin%2C doxazosin%2C metformin%2C cimetidine%2C ranitidine%2C procainamide%2C triamterene%2C flecainide%2C quinidine%2C or any other over-the counter or prescription drug. %0D%0A%0D%0AFood Interactions%0D%0ANo known food interactions. %0D%0A%0D%0ADisease Interactions%0D%0ACaution is advised when taking midodrine. Consult your doctor if you have any of the following%3A urinary retention problems%2C severe heart disease%2C diabetes mellitus%2C vision problems%2C glaucoma%2C pheochromocytoma%2C or thyrotoxicosis. Use of midodrine may cause complications in patients with liver or kidney disease%2C since these organs work together to remove the medication from the body. %0D%0A%0D%0A%5Bb%5Deffets seconds%5B%2Fb%5D%0D%0ASide Effects%0D%0ASerious%0D%0AVery high blood pressure%2C slow heartbeat%2C increased dizziness%2C fainting. Call your doctor immediately. %0D%0A  %0D%0ACommon%0D%0AItching%2C numbness%2C or tingling%2C in the extremities%2C goose bumps%2C chills%2C urinary difficulties. %0D%0A  %0D%0ALess Common%0D%0AHeadache%2C sinus pressure%2C redness of face%2C confusion%2C dry mouth%2C nervousness%2C anxiety%2C skin rash%2C vision problems%2C dizziness%2C dry skin%2C backache%2C gastrointestinal distress%2C gas%2C leg cramps. %0D%0A%0D%0A %0D%0A %0D%0A%0D%0A
2|2|RE%3A MIDODRINE CHLORHYDRATE|Irleana||22:46:18|11/07/2004|[font size="1" color="#5B64B0"]Modifié le 07-11-04 à 22:50  (GMT)[/font][p]Rebonsoir%2C%0D%0A%0D%0APlus s%E9rieusement%2C j%27ai appris qu%27il %E9tait possible de prendre cette mol%E9cule plusieurs ann%E9es %0D%0A%28c%27est rassurant %3B-%29%29...Des %E9tudes ici et ailleurs sont toujours en cours. Pas d%27aplasie m%E9dullaire%2C %E0 priori%2C mais des %E9tudes en neurologie sont envisag%E9es. Pour d%27autres raisons%2Cil existe des doutes sur la descendance%2C il est fortement conseill%E9 de stopper le traitement durant la grossesse..Effet t%E9tratog%E8ne fortement motivant et angoissant.%0D%0A%0D%0AEn revanche la liste d%27effets seconds est plus longue que pr%E9vu...%0D%0ALes informations relatives aux effets seconds sont en effet pour l%27essentiel reprises dans la notice accompagnant le m%E9dicament mais il y a des effets ind%E9sirables plus rares qui n%27y figurent pas.%0D%0ALa liste est longue selon l%27individu %28sensibilit%E9 %E0 la mol%E9cule%29sans que l%27on sache sice dernier %28effet second%29 soit forcemment imputable au produit. %3CNe sont recens%E9s que les %E9l%E9ments s%FBrs%2C les plus fr%E9quents et%2Fou les plus graves. Le reste tient parfois %E0 davantage %E0 de la suspicion qu%27%E0 du r%E9eellement prouv%E9.%3C%0D%0APour les doutes%2C ils sont confirm%E9s %5Bb%5D1%29acc%E9l%E8re le m%E9tabolisme de base%2C %5B%2Fb%5Dprise de poids rendue plus difficile%2C %5Bb%5D2%29effet coup de fouet et coup de pompe en fin de journ%E9e%2C3%29transit ralenti..%5B%2Fb%5DCertains ont d%E9clench%E9 des occlusions%5Bb%5D4%29mauvaise circulation veineuse dans son ensemble %22ph%E9nom%E8ne accentu%E9e%22 y compris les oed%E8mes et le syndrome de Raynaud..%5B%2Fb%5D%0D%0AAutrement la liste d%27effets seconds classique est confirm%E9e%2C avec une pr%E9%E9minence des chairs de poule%2C mictions imp%E9rieuses%2Fet ou br%FBlures%2C quelques rashs et bien rares hypertensions.. %0D%0A%0D%0A%0D%0AAttention%21 %5Bb%5Dgutron%5B%2Fb%5D craint lumi%E8re et grosses chaleurs..Autrement%2C il se fendille et ressemble %E0 de la poudre.. %3A-%28%E0 l%27hosto%2C s%27il n%27est que l%E9g%E9r%E8rement bris%E9%2C ils vous le laissent%2C autrement%2C ils vous le changent.%0D%0A%0D%0ACordialement