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0|0|Article scl%E9rose en plaques %282001%29|Tiquatac2||16:15:17|08/07/2003|Vous pouvez le retrouver sur Pub Med %28NIH%29%0D%0A%0D%0AAssociation between multiple sclerosis and cystic structures in cerebrospinal fluid.%0D%0A%0D%0ABrorson O%2C Brorson SH%2C Henriksen TH%2C Skogen PR%2C Schoyen R.%0D%0A%0D%0ADept. of Microbiology%2C Vestfold Sentralsykehus%2C Tonsberg%2C Norway.%0D%0A%0D%0ABACKGROUND%3A The aim of the study was to search for infectious agents in the cerebrospinal fluid %28CSF%29 of patients with multiple sclerosis %28MS%29. PATIENTS AND METHODS%3A CSF from ten patients with the diagnosis relapsing remitting MS and from five controls without MS were examined by transmission electron microscopy %28TEM%29%2C dark field microscopy %28DF%29%2C interference contrast microscopy %28ICM%29 and UV-microscopic examination of acridine orange staining %28AO%29. All CSF samples from patients and controls were cultured. RESULTS%3A Cystic structures were observed in CSF of all ten patients by AO and TEM. DF revealed eight cyst-positive patients out of nine. One of five control persons had such structures in the CSF%3B this person had suffered from erythema migrans. Spirochete or rod-like structures emerged after culturing two of the MS patient CSF samples and these structures could be propagated. CONCLUSION%3A A significant association of CSF cysts and MS was identified in this small study among residents in a coastal area of southern Norway. The cysts could be of spirochetal origin. Our study may encourage other researchers to study larger patient groups.%0D%0A%0D%0APMID%3A 11787831 %5BPubMed - indexed for MEDLINE%5D%0D%0A